Things where my arms must support my weight: rock climbing, handstands, cartwheels, rope climbing.
Things that irritate my knees: running, jogging, excessive walking downstairs.
Miscellaneous: white-water rafting, canoeing, kayaking, traveling in float planes.
Do I feel this significantly affects my life? No. :)
(*Inspired, in part, by everyone who’s reacted to my weight with “but you do X, Y, Z” and The Fantasy of Being Thin.)